The line between detonation and pre-ignition can be very fine indeed. The resultant increase in cylinder temperature caused by detonation, with its symptoms of pinking (UK), pinging RF & US) and knocking, can lead directly to pre-ignition.
So "WWCS? (What Would Cameron Say?) Detonate long enough and pre-ignition will follow." http://www.contactmagazine.com/Issue54/EngineBasics.html
This is the best article I have come across to explain detonation and pre-ignition and the damage each will cause
Be sure to read the last paragraph "Muddy Water."
So while thickening the exhast valve margin, radiusing the edges of piston valve pockets, increasing the width of the valve's seat area, insuring the copper head gasket isn't sticking into the cylinder bore after a rebore, or installing proper grade spark plug, etc. might not prevent damage induced by detonation; it can help prevent detonation induced pre-ignition.